Pat salmon fillets dry with paper towels and season both sides with garlic powder, paprika, salt, and pepper.

Heat a large nonstick or cast-iron skillet over medium-high heat. Add butter and let it melt until foaming.

Place salmon fillets, skin side down, in the hot skillet. Cook undisturbed for 4–5 minutes until the edges turn golden brown.

Flip each fillet carefully and cook an additional 2–3 minutes, or until the internal temperature reaches 125°F for medium-rare, or 145°F for well done.

Remove from heat and let rest for 1 minute before serving.